Ekkehard Grünig Selected Research

7-(N-(3-aminopropyl)amino)heptan-2-one

6/2015	Stress Doppler echocardiography for early detection of systemic sclerosis-associated pulmonary arterial hypertension.
9/2013	Efficacy of exercise training in pulmonary arterial hypertension associated with congenital heart disease.
1/2013	Hemodynamic and genetic analysis in children with idiopathic, heritable, and congenital heart disease associated pulmonary arterial hypertension.
6/2012	Exercise training in pulmonary arterial hypertension associated with connective tissue diseases.
5/2012	Treatment of pulmonary arterial hypertension in connective tissue disease.

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Ekkehard Grünig Research Topics

Disease

61	Pulmonary Arterial Hypertension 10/2022 - 01/2007
50	Pulmonary Hypertension 10/2022 - 12/2005
13	Familial Primary Pulmonary Hypertension 10/2022 - 06/2003
6	Heart Diseases (Heart Disease) 08/2022 - 01/2010
6	Chronic Obstructive Pulmonary Disease (COPD) 01/2021 - 06/2015
5	Disease Progression 10/2021 - 02/2015
4	Lung Diseases (Lung Disease) 10/2022 - 06/2015
4	Heart Failure 12/2016 - 08/2013
3	Inflammation (Inflammations) 11/2021 - 01/2018
3	Headache (Headaches) 10/2021 - 01/2020
3	Hypotension (Low Blood Pressure) 01/2021 - 05/2015
3	Emphysema 07/2020 - 01/2015
3	Systemic Scleroderma (Systemic Sclerosis) 10/2019 - 06/2015
3	Congenital Heart Defects (Congenital Heart Defect) 09/2013 - 05/2012
2	Iron Deficiencies 11/2021 - 12/2018
2	Nausea 10/2021 - 01/2020
2	Diarrhea 10/2021 - 01/2020
2	Hemoptysis 01/2021 - 12/2020
2	Hemorrhage 01/2021 - 12/2020
2	Dyspnea (Shortness of Breath) 01/2020 - 07/2013
2	Infections 12/2018 - 10/2018
2	Hereditary Hemorrhagic Telangiectasia 10/2014 - 12/2013
2	Connective Tissue Diseases (Connective Tissue Disease) 06/2012 - 05/2012
1	Vascular Remodeling 01/2022
1	Anemia 11/2021
1	Pulmonary Embolism 01/2021
1	Cough 01/2021
1	Dyspepsia (Indigestion) 01/2021
1	Respiratory Tract Infections (Respiratory Tract Infection) 01/2021
1	Coronary Disease (Coronary Heart Disease) 12/2020
1	Obesity 12/2020
1	Hypertension (High Blood Pressure) 12/2020
1	Diabetes Mellitus 12/2020
1	Vomiting 01/2020
1	Flushing 01/2020
1	Multiple Sclerosis 07/2019
1	Sepsis (Septicemia) 10/2018
1	Lung Neoplasms (Lung Cancer) 01/2018

Drug/Important Bio-Agent (IBA)

21	riociguatIBA 10/2021 - 07/2013
10	Soluble Guanylyl CyclaseIBA 01/2021 - 07/2013
9	Endothelin Receptor AntagonistsIBA 07/2020 - 12/2011
8	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 01/2022 - 06/2003
6	Brain Natriuretic Peptide (Natrecor)FDA Link 10/2022 - 07/2013
6	pro-brain natriuretic peptide (1-76)IBA 01/2022 - 07/2013
6	Tadalafil (Cialis)FDA Link 10/2021 - 02/2015
6	ProstaglandinsIBA 07/2020 - 12/2011
5	Carbon MonoxideIBA 10/2022 - 12/2014
5	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 01/2021 - 02/2015
5	Phosphodiesterase 5 InhibitorsIBA 01/2020 - 12/2011
5	treprostinil FDA Link 01/2020 - 01/2016
5	ambrisentan FDA Link 10/2019 - 08/2015
5	hydralazine 4-anisaldehyde hydrazoneIBA 04/2017 - 01/2013
5	7-(N-(3-aminopropyl)amino)heptan-2-oneIBA 06/2015 - 05/2012
4	Epoprostenol (Prostacyclin)FDA LinkGeneric 01/2021 - 01/2019
4	Biomarkers (Surrogate Marker)IBA 12/2020 - 01/2014
4	Oxygen (Dioxygen)IBA 12/2018 - 08/2013
4	Sildenafil Citrate (Viagra)FDA Link 01/2017 - 02/2015
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2020 - 01/2010
3	Pharmaceutical PreparationsIBA 01/2019 - 05/2015
3	Proteins (Proteins, Gene)FDA Link 01/2018 - 11/2016
2	4- ((1,4,8,11- tetraazacyclotetradec- 1- yl)methyl)benzoic acidIBA 08/2022 - 11/2019
2	macitentanIBA 10/2021 - 01/2017
2	NADPH Oxidases (NAD(P)H oxidase)IBA 07/2020 - 01/2020
2	MicroRNAs (MicroRNA)IBA 01/2020 - 01/2020
2	4-S-(propionic acid)sulfidocyclophosphamide (PASP)IBA 11/2019 - 10/2013
2	Bosentan (Tracleer)FDA Link 01/2017 - 12/2015
2	Type II Bone Morphogenetic Protein Receptors (Bone Morphogenetic Protein Receptor Type II)IBA 02/2016 - 10/2004
2	activin receptor type II-A (activin A receptor, type II)IBA 10/2014 - 12/2013
1	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 01/2022
1	Messenger RNA (mRNA)IBA 01/2022
1	alunacedase alfaIBA 01/2022
1	Indicators and Reagents (Reagents)IBA 11/2021
1	Ferritins (Ferritin)IBA 11/2021
1	IronIBA 11/2021
1	selexipagIBA 10/2021
1	Epoprostenol ReceptorsIBA 01/2021
1	SmokeIBA 01/2020
1	NADPH Oxidase 2IBA 01/2020
1	Peroxynitrous Acid (Peroxynitrite)IBA 01/2020
1	Superoxides (Superoxide)IBA 01/2020
1	3-nitrotyrosineIBA 01/2020
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2020
1	Interferon-betaIBA 07/2019
1	InterferonsIBA 07/2019
1	Endothelins (Endothelin)IBA 01/2019
1	GoldIBA 01/2019
1	Ion Channels (Ion Channel)IBA 12/2018
1	DiureticsIBA 12/2018
1	Transcription Factors (Transcription Factor)IBA 12/2018
1	AnticoagulantsIBA 12/2018
1	Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)IBA 01/2018
1	AntibodiesIBA 01/2018
1	Surface-Active Agents (Surfactants)IBA 01/2018
1	Circulating MicroRNAIBA 01/2018

Therapy/Procedure

46	Therapeutics 10/2022 - 01/2007
6	Endarterectomy (Thromboendarterectomy) 01/2021 - 01/2012
1	Implantable Infusion Pumps 01/2020
1	Contraception (Birth Control) 12/2018
1	Catheters 10/2018
1	Mechanical Ventilators (Ventilator) 01/2018